RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
H19
RNA ID
RNA Type
lncrna
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Dual-luciferase reporter assay etc.
Target
Col1a1
Pathway
NA
PubMed ID
Title
The effect of H19-miR-29b interaction on bleomycin-induced mouse model of idiopathic pulmonary fibrosis
Year
2016
Function
"H19 play a promotive role in bleomycin-induced epithelial-mesenchymal transition of alveolar epithelial cell through miR-29b regulation. H19 expression was positively correlated with COL1A1 and Acta2 expression; H19 knockdown inhibited COL1A1 and Acta2 expression. Moreover, H19 interacted with miR-29b through directly binding to the 3'UTR; MiR-29b inhibited COL1A1 expression by directly binding to the 3'UTR. In conclusion, we revealed the promotive effect of H19 on BLM-induced IPF, and demonstrated the mechanism by which H19/miR-29b interaction exerts its effect on regulating pulmonary fibrosis."
RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
H19
RNA ID
RNA Type
lncrna
Alteration Pattern
interact with miRNA
Species
mus musculus
Detection Methods
qPCR; Knockdown etc.
Target
Lsp1; Tnnt3; Mrpl23; Igf2; AC013548.1
Pathway
NA
PubMed ID
Title
The effect of H19-miR-29b interaction on bleomycin-induced mouse model of idiopathic pulmonary fibrosis
Year
2016
Function
"Moreover, H19 interacted with miR-29b through directly binding to the 3'UTR; miR-29b inhibited COL1A1 expression by directly binding to the 4'UTR."